IDENTIFICATION
Common name: Cartap
Other name: Cartap (BSI, E-ISO,（m）F-ISO,JMAF)/cartap hydrochloride
Iupac name: S, S’-(2-dimethylaminorimthylene) bis (thiocarbamate)
Chemical abstracts name: S, S’-[2-(dimethylamino)-1, 3-propamediyl] dicarbamothioate
Type: Insecticide for Agriculture
CAS RN: [15263-53-3],[15263-52-2]
EEC No: 239-309-2
Development code: TI-1258
M.F.: C7H15N3O2S2 / C7H16 CIN3O2S2
Mol Wt: 237.3 / 273.8
PHYSICAL CHEMISTRY
Form (appearance): Colourless crystalline, slightly hygroscopic solid with slight odour.
M.P.: 179-181℃(decomp)
V.P.: Negligible
Solubility. In water c. 200g/1(25℃). Very slightly soluble in methanol and ethanol. Insoluble in acetone, diethyl ether, ethyl acetate, chloroform, benzene, and hexane
Stability: Stable in acidic conditions, but hydrolysed in neutral or alkaline media
APPLICATION
Formulation types: DP; GR; SP
Biochemistry: Analogue or propesticide of the natural toxin nereistoxin. Nicotinergic acetylcholine blocker, causing paralysis by blocking cholinegic transmissions in the central nervous systems of insects
Mode of action: Systemic insecticide with stomach and contact action. Insects discontinue feeding, and die of starvation
Uses: Cartap hydrochloride is used, at c.a 0.4-1.0kg/ha, for control of chewing and sucking insects (particularly Lepidoptera and Coleoptera), at almost all stages of development, on many crops,including rice (Chilo suppressalis, Cnaphalocroclis, Lissorhoptrus oryzophilus and rice-leaf beetle), potatoes, cabbage and other vegetables(Agromyzidae,Leptinotarsa decemlineata and Plutella xylostella); also on soya beanuts, sunflowers, maize, sugar beet, wheat , pearley, pome fruit, stone fruit, citrus fruit, vines, chestnuts,ginger, tea, cotton, and sugar cane
Phytotoxicity: May be phytotoxic to cotton, tobacco, and apples, under certain soil and climatic conditions
Compatibility: Not compatible with pesticides which are alkaline
MAMMALIAN TOXICOLOGY
Reviews: FAO/WHO 74 see part 2 of the Bibliography.
Oral: Acute oral LD50 for male rats 345, female rats 325, male mice 150, fernale mice 154 mg/kg.
Skin and eye: Acute percutaneous LB50 for mice >1000 mg/kg: no irritation to skin or eyes in rabbits.
Inhalation: LC50 (6 h) for rats >0.54 mg/l.
Noel: (2 y) for rats 10 mg/kg b.w. daily; (1.5 y) for mice 20 mg/kg b.w. daily.
ADI: (JMPR) ADI withdrawn [1995]. |[cartap]
Toxicity: WHO (a.i.) II; EPA (formulation) II
EC hazard: Xn; R21/22
ECOTOXICOLOGY
Fish: LC50 for carp 1.6 mg/l (24 h) and 1.0 mg/l (48 h).
Other aquatic spp. LC50 (24 h) for Moina macrocopa 12.5-25 mg/l.
Worms: /Bees: Moderately toxic to honeybees.
ENVIRONMENTAL FATE
Animals: EHC 76 (WHO, 1988).
In rats, the carbonyl carbon is hydrolysed, and the sulfur oxidised, with N demethylation of thiomethyl derivatives. No accumulation occurs in tissues. Rapidly excreted in the urine.
Soil/Environment: DT50 in soil c. 3 d
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